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It is the drug of choice for primary generalized epilepsies and is also approved for the treatment of partial seizures. Patients with coexistent migraine headache or neuropathic pain may benefit from this drug. Drugs that do not reduce the effectiveness of hormonal contraception Ethosuximide. For maintenance therapy, the dose is adjusted to the minimum effective level, usually to 1, mg daily.
OXC is approved for monotherapy or adjunctive therapy in patients with partial and secondary generalized seizures. Because of its potentially fatal toxic effects in particular, the small but definitive risk of aplastic anemia and hepatic failure , use of felbamate is restricted to patients with severe partial epilepsy or Lennox-Gastaut syndrome who do not respond to other medications. It is chemically unrelated to any of the other AEDs; it is a small-ringed structure related to sulfonamide antibiotics with pH-dependent solubility in water. Despite recent developments in the non-medical therapy of epilepsy, the prophylactic use of anticonvulsant drugs remains the mainstay of treatment.
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